Usual Dose & Administration
Usual Adult Dose
1 g q8h
Adjustment of Dose & Administration
Indication-Specific Adjustment
| Indication | CrCl (mL/min) | |||
| >50 | 30-50 | 10-29 | <10, IHD | |
| Genital Herpes | 500-1000mg q12h | 500-1000mg q12h | 500-1000mg q24h | 500mg q24h |
| Herpes Zoster | 1g q8h | 1g q12h | 1g q24h | 500mg q24h |
| Herpes labialis (cold sores) | 2g every 12 hours for 2 doses starting at the first sign or symptom of lesions | 1g q12h for 2 doses | 500mg q12 for 2 doses | 500mg as a single dose |
Cost Index
$$ (11-20)
General Notes
- Up-to-date cost information, click here
- IV antimicrobials outpatient (OPAT) dosing, click here
- Obesity dosing weight recommendations here
- Helpful drug-drug interaction check website here
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.