Meropenem-vaborbactam (Vabomere) (IV)

Usual Dose & Administration

4 g IV q8h

Adjustment of Dose & Administration

Renal Adjustment

Indication	eGFR (mL/min/1.73m2)
	>50	30-49	15-29	<15, IHD	CRRT
All indications including: Intra-abdominal Pneumonia UTI	4g IV q8h	2g IV q8h	2g IV q12h	1g IV q12h	2g IV q8-12h

All doses are administered over 3 hours

 

Please find optimal dosing recommendations here: https://www.customid.org/policy/duhs-adult-beta-lactam-dosing-policy 

Drug-Specific Information

Meropenem-vaborbactam is a new carbapenem/beta-lactamase inhibitor combination.  It may be used to treat KPC-producing carbapenem resistant Enterobacteriacae.

Restricted Use

ID Consult required

Cost Index

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General Notes

1. Up-to-date cost information, click here 
2. IV antimicrobials outpatient (OPAT) dosing, click here
3. Obesity dosing weight recommendations here
4. Helpful drug-drug interaction check website here 
5. When dosing guidance is provided it is important to note the following:

Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.