Criteria & Principles
NOTE: IV moxifloxacin is currently on shortage. Anticipated next release of product is Q4 2026. This shortage does not impact oral formulations of moxifloxacin.
Attachment to the right includes the following guidance tables for ADULT patients with Traumatic Injury or Procedures
- Prophylactic and Periprocedural Antibiotics for Adult Patients with Trauma
- Facial Fracture Antibiotic Prophylaxis and Duration for Adults
- Open Fracture Prophylaxis for Adults
References
1. Goldberg SR, Anand RJ, Como JJ, et al. Prophylactic antibiotic use in penetrating abdominal trauma: An Eastern Association for the Surgery of Trauma practice management guideline. Journal of Trauma and Acute Care Surgery. 2012;73(5):S321-S325.
2. Appelbaum RD, Farrell MS, Gelbard RB, et al. Antibiotic prophylaxis in injury: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document. Trauma Surg Acute Care Open. 2024;9(1):e001304.
3. Forrester JD, Wolff CJ, Choi J, Colling KP, Huston JM. Surgical Infection Society Guidelines for Antibiotic Use in Patients with Traumatic Facial Fractures. Surg Infect (Larchmt). 2021;22(3):274-282.
4. Jennifer JF, Sofya HA, Cory JV, et al. Antibiotic prophylaxis for tube thoracostomy placement in trauma: a practice management guideline from the Eastern Association for the Surgery of Trauma. Trauma Surgery & Acute Care Open. 2022;7(1):e000886.
5. Ganga A, Leary OP, Sastry RA, et al. Antibiotic prophylaxis in penetrating traumatic brain injury: analysis of a single-center series and systematic review of the literature. Acta Neurochir (Wien). 2023;165(2):303-313.
6. Fisher CG, Kacica MA, Bennett NM. Risk factors for cartilage infections of the ear. Am J Prev Med. 2005;29(3):204-209.
7. Renninger CH, Tedesco NS, Strelzow J. American Academy of Orthopaedic Surgeons Appropriate Use Criteria: Prevention of Surgical Site Infections After Major Extremity Trauma. J Am Acad Orthop Surg. 2023;31(10):497-504.
8. Strelzow J, Tedesco NS, Renninger CH. American Academy of Orthopaedic Surgeons Appropriate Use Criteria: Prevention of Surgical Site Infections After Major Extremity Trauma. J Am Acad Orthop Surg. 2023;31(2):e68-e72.
9. Tunkel AR, Hasbun R, Bhimraj A, et al. 2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis. 2017;64(6):e34-e65.
10. Joint Trauma System – Department of Defense Center of Excellence for Trauma Clinical Practice Guidelines. https://jts.health.mil/index.cfm/PI_CPGs/cpgs
11. Centers for Disease Control and Prevention. Clinical Guidance for Wound Management to Prevent Tetanus. https://www.cdc.gov/tetanus/hcp/clinical-guidance/index.html Accessed 07/07/2025.