Usual Dose & Administration
Usual Adult Dose
1 double strength tablet PO q12h
Adjustment of Dose & Administration
Indication-Specific Adjustment
| Indication (TREATMENT)* | CrCl (mL/min) | |||
| >30 | 10-30 | < 10, IHD | CRRT | |
|
PCP Stenotrophomonas** Nocardia
|
5 mg/kg/dose q8h | 5 mg/kg/dose q8-12h |
5-7.5 mg/kg/dose q24h (administer dose after dialysis on dialysis days) |
5-7.5 mg/kg/dose q12h |
|
UTI |
1 DS tab q12h | 1 DS tab q24h | 1 DS tab q24h
(administer dose after dialysis on dialysis days) |
1 DS tab q12h |
|
Cellulitis Non-TB Mycobacterium |
1-2 DS tabs q12h | 1-2 DS tabs q24h | 1-2 DS tabs q24h
(administer dose after dialysis on dialysis days) |
1-2 DS tabs q12h |
| Bloodstream infection | 5 mg/kg/dose q12h | 2.5 mg/kg/dose q12h | 2.5 mg/kg q24h (administer dose after dialysis on dialysis days) | 5 mg/kg/dose q12h |
*When using weight-based dosing in obese patients (BMI >30 kg/m2) use adjusted bodyweight (https://www.customid.org/policy/antimicrobial-dosing-adult-obese-patients)
**For Stenotrophomonas: Can consider lower dosing (3-4 mg/kg q8h) if intolerance, adverse effects, or for mild infections. Adjust for renal function.
***mg/kg dosing based on TMP component***
| Indication (PROPHYLAXIS) | |
| Small Bowel/Multivisceral transplant | 1 DS tab MWF x 1 yr |
| Liver transplant | 1 DS tab MWF x 3 mo |
| Kidney/Pancreas transplant | 1 DS tab MWF x 1 yr |
| Heart transplant | 1 SS tab daily x 1 yr |
| Lung transplant |
1 SS tab daily indefinitely (1 SS tab MWF for CrCl < 30 mL/min) |
| AML, ALL, MDS |
1 SS tab daily throughout induction and consolidation |
|
Lymphoma regimens (hyper CVAD, EPOCH, R-EPOCH, ICE, RICE
|
1 SS tab daily throughout induction and consolidation |
| BMT: NMA Allo, MA Allo, MA Cord | See guideline for recommendations |
| Spontaneous bacterial peritonitis | 1 DS tab daily |
Drug-Specific Information
Single strength tablet: 400mg sulfamethoxazole/80mg trimethoprim
Double strength tablet: 800mg sulfamethoxazole/160mg trimethoprim
Injection: 80mg sulfamethoxazole-16mg trimethoprim/mL
Cost Index
$ (1-10)
General Notes
- Up-to-date cost information, click here
- IV antimicrobials outpatient (OPAT) dosing, click here
- Obesity dosing weight recommendations here
- Helpful drug-drug interaction check website here
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.