Fluconazole (IV and PO)

Adjustment of Dose & Administration

Indication-Specific Adjustment

Single dose indications:

• Mild intertrigo: 200 mg once
• Candida vaginitis: 150 mg once

Prophylaxis:

• 9100 Hematology Oncology (HOA) Anti-infective Prophylaxis Protocol
• Adult Stem Cell Transplantation Infection Prophylaxis Guidelines

Adult Mild to Moderate Infections

Adult Invasive/Serious Infections (ID Consult Required for Candidemia)

 

Renal Adjustment

See above dosing table.

Drug-Specific Information

Oral bioavailability approximately 100%. Therefore, consider oral formulation unless patient unable to take oral medication, severe infections, or when concerns exist regarding absorption.

Dose conversion: 1:1 IV to PO

General Notes

1. Up-to-date cost information, click here 
2. IV antimicrobials outpatient (OPAT) dosing, click here
3. Obesity dosing weight recommendations here
4. Helpful drug-drug interaction check website here 
5. When dosing guidance is provided it is important to note the following:

Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.