Adjustment of Dose & Administration
Indication-Specific Adjustment
Single dose indications:
- Mild intertrigo: 200 mg once
- Candida vaginitis: 150 mg once
Prophylaxis:
- 9100 Hematology Oncology (HOA) Anti-infective Prophylaxis Protocol
- Adult Stem Cell Transplantation Infection Prophylaxis Guidelines
Adult Mild to Moderate Infections
Adult Invasive/Serious Infections (ID Consult Required for Candidemia)
Renal Adjustment
See above dosing table.
Drug-Specific Information
Oral bioavailability approximately 100%. Therefore, consider oral formulation unless patient unable to take oral medication, severe infections, or when concerns exist regarding absorption.
Dose conversion: 1:1 IV to PO
General Notes
- Up-to-date cost information, click here
- IV antimicrobials outpatient (OPAT) dosing, click here
- Obesity dosing weight recommendations here
- Helpful drug-drug interaction check website here
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.