Usual Dose & Administration
Usual Adult Dose
300 mg PO q6h
Usual Adult Dose, alternate option
450 mg PO q8h
Adjustment of Dose & Administration
Indication-Specific Adjustment
PCP pneumonia: 300 mg q6h
CNS toxoplasmosis: 300-600 mg q6h
General Notes
- Up-to-date cost information, click here
- IV antimicrobials outpatient (OPAT) dosing, click here
- Obesity dosing weight recommendations here
- Helpful drug-drug interaction check website here
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.