Usual Dose & Administration
Usual Adult Dose
500 mg PO q6h
Adjustment of Dose & Administration
Indication-Specific Adjustment
| Indication | CrCl (mL/min) | ||
| >=50 | 10-50 | <10, IHD | |
| Uncomplicated UTI | 500mg q12h | 500mg q12h | 500mg q24h |
| Complicated UTI, skin and skin structure infections, respiratory tract infections | 500mg q6h | 500mg q8h | 500mg q12h |
| Enterobacterales (E. coli, Klebsiella spp., & Proteus mirabilis) bloodstream infection | 1000mg q6h | 1000mg q8h | 1000mg q12h |
| Bone and Joint infection | 1000mg q6-8h | 1000mg q8-12h | 1000mg q24h |
Cost Index
$ (1-10)
General Notes
- Up-to-date cost information, click here
- IV antimicrobials outpatient (OPAT) dosing, click here
- Obesity dosing weight recommendations here
- Helpful drug-drug interaction check website here
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.