Duke University Hospital Duke Raleigh Hospital Duke Regional Hospital

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Adult Pediatric All

Usual Dose & Administration

300 mg PO q12h

Adjustment of Dose & Administration

Renal Adjustment

Indication                                CrCl (mL/min)
>=30 <30 IHD
Bronchitis, CAP, uncomplicated skin AND/OR subcutaneous tissue, maxillary sinusitis, pharyngitis, tonsillitis, otitis media 300mg q12h 300mg once daily 300 mg q48h and 300 mg at the end of each hemodialysis session (with subsequent doses given every other day) 

 

Cost Index

$ (<10)

General Notes

  1. Up-to-date cost information, click here 
  2. IV antimicrobials outpatient (OPAT) dosing, click here
  3. Obesity dosing weight recommendations here
  4. Helpful drug-drug interaction check website here 
  5. When dosing guidance is provided it is important to note the following:

Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.