Cefazolin (IV)

Usual Dose & Administration

Usual Adult Dose

2 g IV q8h

Adjustment of Dose & Administration

Indication-Specific Adjustment

Indication	CrCl (mL/min)
	>30	10-29	<10, HD	CRRT
bacteremia (including MSSA), osteomyelitis, endocarditis, pneumonia, wound infections	2g q8h	1g -2g q12h	1g q24h OR 2g/2g/3g post HD	1g q8h
UTI (complicated)	1g q8h	500mg - 1gm q12h	500mg q24h OR 1g/1g/2g post HD	500mg q12h

Surgical prophylaxis:

weight <120 kg: 2g

weight >=120 kg: 3g

Drug-Specific Information

• Methicillin-sensitive isolates only
  • Cefazolin should be used in cases where pathogen is susceptible to cefazolin or methicillin (ie excludes MRSA, MRSE and coagulase-negative staphylococci)

Cost Index

$ (1-10)

General Notes

1. Up-to-date cost information, click here 
2. IV antimicrobials outpatient (OPAT) dosing, click here
3. Obesity dosing weight recommendations here
4. Helpful drug-drug interaction check website here 
5. When dosing guidance is provided it is important to note the following:

Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.