Usual Dose & Administration
500 mg PO q12h
Adjustment of Dose & Administration
Indication-Specific Adjustment
*For UTI use, only use cefadroxil IF cefazolin MIC < 2 mcg/mL (see below for further details)
| Indication | CrCl ≥ 40 mL/min | CrCl 20-40 mL/min | CrCl < 20 mL/min |
| SSTI, uncomplicated UTI/cystitis | 500 mg PO q12h | 500 mg PO q24h | 500 mg PO q48h |
| Complicated UTI, pyelonephritis | 1000 mg PO q12h | 500 mg PO q12h | 500 mg PO q24h |
Drug-Specific Information
*CLSI recommends using cefazolin as a surrogate test for oral cephalosporins and uncomplicated UTIs. Cefadroxil is NOT one of the oral cephalosporins listed by CLSI due to lower cefazolin surrogate accuracy (91.6%) at a breakpoint < 16 mcg/mL. However, cefazolin surrogate test accuracy improves to ~100% for cefadroxil when using a cefazolin breakpoint < 2 mcg/mL (Diagn Microbiol Infect Dis 2020). Urine culture reporting at DUH uses a cefazolin breakpoint < 2 mcg/mL in E. coli, K. pnuemoniae, & P. mirabilis to categorize Susceptible "S" isolates.
General Notes
- Up-to-date cost information, click here
- IV antimicrobials outpatient (OPAT) dosing, click here
- Obesity dosing weight recommendations here
- Helpful drug-drug interaction check website here
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.