Adjustment of Dose & Administration
Indication-Specific Adjustment
| Indication | CrCl (mL/min)* | |||
|
>50 |
31-50 | 16-30 | </= 15, iHD^ | |
| All indications |
2.67g ONCE followed by 2g IV q6h |
2.67g ONCE followed by 1g IV q6h | 1.8g ONCE followed by 900mg IV q8h | 1.33g ONCE followed by 900mg IV q12h |
*each dose infused over 3 hours
^for iHD dosing: administer dose after hemodialysis on dialysis days.
Drug-Specific Information
Aztreonam/avibactam susceptibility testing is not routinely performed.
Add metronidazole if sufficient anaerobic coverage is required.
Restricted Use
ID Consult Required
General Notes
- Up-to-date cost information, click here
- IV antimicrobials outpatient (OPAT) dosing, click here
- Obesity dosing weight recommendations here
- Helpful drug-drug interaction check website here
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.