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Adult Pediatric All

Usual Dose & Administration

500 mg PO q12h

Adjustment of Dose & Administration

Indication-Specific Adjustment

*For UTI use, only use cefadroxil IF cefazolin MIC < 2 mcg/mL (see below for further details)

Indication CrCl ≥ 40 mL/min CrCl 20-40 mL/min CrCl < 20 mL/min
SSTI, uncomplicated UTI/cystitis 500 mg PO q12h 500 mg PO q24h 500 mg PO q48h
Complicated UTI, pyelonephritis 1000 mg PO q12h 500 mg PO q12h 500 mg PO q24h

 

Drug-Specific Information

*CLSI recommends using cefazolin as a surrogate test for oral cephalosporins and uncomplicated UTIs. Cefadroxil is NOT one of the oral cephalosporins listed by CLSI due to lower cefazolin surrogate accuracy (91.6%) at a breakpoint < 16 mcg/mL. However, cefazolin surrogate test accuracy improves to ~100% for cefadroxil when using a cefazolin breakpoint < 2 mcg/mL (Diagn Microbiol Infect Dis 2020). Urine culture reporting at DUH uses a cefazolin breakpoint < 2 mcg/mL in E. coli, K. pnuemoniae, & P. mirabilis to categorize Susceptible "S" isolates.

General Notes

  1. Up-to-date cost information, click here 
  2. IV antimicrobials outpatient (OPAT) dosing, click here
  3. Obesity dosing weight recommendations here
  4. Helpful drug-drug interaction check website here 
  5. When dosing guidance is provided it is important to note the following:

Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.